Recombinant Human Growth Hormone Treatment for Dilated Cardiomyopathy in Children

Recombinant human growth hormone treatment for dilated cardiomyopathy in children.

OBJECTIVE Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure among children and is often progressive despite maximal medical therapy. Heart failure is characterized by a number of neurohormonal abnormalities, including derangements in the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) signaling axis. Decreased serum levels of GH, which acts on cardiac myocy...

Evaluation of Heat Induction Strategy for Recombinant Human Growth Hormone Expression in Fed-Batch Fermentation

Role of nitric oxide in the vasodilator effect of recombinant human growth hormone in patients with dilated cardiomyopathy.

OBJECTIVE Dilated cardiomyopathy is characterized by elevated arterial vascular resistance and impaired nitric oxide (NO)-dependent vasodilation. Insulin-like growth factor-I (IGF-I) has been shown to stimulate endothelial NO-synthase resulting in endothelium-dependent vasodilation. Growth hormone (GH) substitution therapy leads in GH-deficient patients to significant increases of IGF-I which m...

Long-term safety of recombinant human growth hormone in children.

BACKGROUND Between 1985 and 2006, the National Cooperative Growth Study (NCGS) monitored the safety and efficacy of recombinant human growth hormone (rhGH) in 54,996 children. METHODS Enrolled patients were followed until rhGH discontinuation. Investigators submitted adverse event reports for targeted events or those potentially rhGH-related. RESULTS Early concerns about de novo leukemia in...

The Effect of Growth Hormone on Idiopathic Dilated Cardiomyopathy

ObjectiveIdiopathic dilated cardiomyopathy (IDCM) is currently an important cause of mortality and morbidity due to chronic heart failure. The aim of our study was to assess whether there could be any clinical and /or echocardiographic improvement in patients with IDCM who had undergone treatment of recombinant human growth hormone (GH). MethodsFourteen patients with IDCM and moderate heart fai...